Arbeitsgruppe : Tissue engineering
Engineering von Hart- und Weichgeweben
In our tissue engineering lab, we focuse on engineering and regeneration of tissues for maxillofacial reconstruction, i.e. bone and soft tissues, with special impact on strategies for immediate vascularization. Vascularization may be accomplished in vitro, in specialized bioreactors or in vivo.
Adipose tissue
Adipose tissue provides shape and volume of the outer contour of
the body and preserves mobility of tissue layers. Soft tissue
augmentation has strong significance in many instances of plastic and
reconstructive surgery. Engineering of adipose tissue may also be model
for the engineering of other soft tissues. Problems to be solved are
for instance the evaluation of suited carrier materials, the problem of
nutrition and vascularization. We developed an in vitro adipose tissue
engineering and succeeded in engineering of viable, completely
differentiated constructs in vitro, which were transplanted successfully
in SCID-mice.
Bone regeneration
Bone repair may be accomplished by engineering (with cell
transplantation) and also by regenerative strategies (without cell
transplantation). A further question is the source of cells, which
might be mesenchymal progenitors from bone marrow or other tissues like
adipose tissue. Bone engineering and regeneration strategies are
followed with other institutions in the Leipzig-Halle region
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